In take of selenium may prevent bladder cancer
Selenium consumed through wheat containing higher levels of selenium grown in selenium rich soils.
Researchers found that reduction in risk of cancer for moderate smokers and cancer affected people due to particular gene – p53.
Selenium might prevent a particular section of persons like women who develop bladder cancer or stop particular types of tumors formed through p53 pathway from developing.
Researchers say this gives clue to prevent tumors in bladders in the near future and may lead to chemo preventive methods.
Levels of selenium is falling steadily in Europe since European union imposed levies on wheat imports from the US, where wheat contains higher levels of selenium due to soil selenium contents are more. This has resulted in drop of average consumption of selenium in UK from a level of 60 to 34 micro grams per day. Some of them even were calling to enrich soil and fertilizers with selenium to increase consumption of the public.
The European recommended daily intake (RDI) is 65 micrograms. The recommended EC Tolerable Upper Intake Level for selenium is 300 micrograms per day. Selenium enriched fertilizers are used in Finland.
Researchers studied persons diagnosed with bladder cancer recently by measuring levels of selenium in the toenails of 767 people (76% male having average age of 62) and 1,108 persons population in general (61% male having average age of 61) though no connections were ascertained between levels of selenium and bladder cancer risk for the entire population group. Apparent risk reductions found in the case of females (34%), moderate smokers (39%) and others having p53 positive cancer (43%).
Researchers said that there are different reasons by which bladder cancer evolves and believed one of the main reasons behind evolving of bladder cancer is associated with alterations in the p53 gene. With these alterations, bladder cancers evolve into more serious and advanced cancer. Researchers are going to repeat this test in a larger scale in order to find out relation between selenium and bladder cancer in females and recently diagnosed bladder cancer patients and those having with p53 tumors.
Researchers also believe selenium may prevent bladder cancer but not prostate cancer. In a recently concluded study published in American Journal of Clinical Nutrition, information from EPIC ( European Prospective Investigation into Cancer and Nutrition study finds that selenium levels in blood might not show reduction in the risk of cancer formed in prostate. To prove these researchers conducted trials on men affected by prostate cancer and 1,059 men without prostate cancer.
Selenium concentrations in blood levels were not related to risk of developing cancer in prostate.
During trials stage or grade of the cancer and smoking status of the patients were taken into consideration. Researchers said that Selenium concentration in plasma was not related to cancer in prostate risk in this big group of European men.
This study clearly states that selenium content in blood levels is in no way associated with cancer in prostate. However, some other studies show there might be connection between selenium and bladder cancer in women, cancer through p53 gene and as long as intake of selenium in food via wheat or other grains may prevent formation of tumors in bladder and cancerous cell formation and production in bladder.
Levels of selenium also reduce risk of bladder cancer for moderate cigarette smokers compared to low levels of selenium in taking which may lead to potential growth of bladder cancer and people having p53 gene susceptible to alterations resulting in bladder tumor or cancer.
This type of bladder cancer is more advanced and serious one compared to others. Selenium in take might significantly reduce risk of bladder cancer.
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